Format

Send to

Choose Destination
Int J Tuberc Lung Dis. 2017 Aug 1;21(8):916-921. doi: 10.5588/ijtld.16.0043.

Diabetes increases the risk of recent-transmission tuberculosis in household contacts in São Paulo, Brazil.

Author information

1
Department of Medicine, University of California, San Francisco, USA; Zuckerberg San Francisco General Hospital, San Francisco, California, USA.
2
Department of Public Health, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil.
3
School of Public Health, University of São Paulo, São Paulo, São Paulo, Brazil.
4
School of Public Health, University of California, Berkeley, Berkeley, California, USA.

Abstract

SETTING:

A cohort of household contacts of tuberculosis (TB) index cases from four public health clinics in São Paulo, Brazil.

OBJECTIVE:

To measure the association between diabetes mellitus (DM) among household contacts and recent-transmission TB (RT TB).

DESIGN:

Index TB cases (n = 263) identified from 2001 to 2002 in São Paulo, whose household contacts (n = 1383) were monitored for active TB until December 2010.

RESULTS:

From 2001 to 2010, there were 29 cases of RT TB among household contacts (cumulative incidence 2.1%, 95%CI 1.4-2.9). DM in household contacts was associated with RT TB (OR 3.96, 95%CI 1.33-11.79) even after adjustment for human immunodeficiency virus (HIV) status, smoking and alcohol use (adjusted OR [aOR] 3.21, 95%CI 1.01-10.19). HIV infection was also associated with RT TB (OR 6.40, 95%CI 1.40-29.40; aOR 4.81, 95%CI 0.96-24.18). Household contact DM was not associated with non-RT TB (OR 1.27, 95%CI 0.30-5.40). The time to diagnosis of TB was shorter in household contacts with and without DM (P = 0.035) and in household contacts with and without HIV (P = 0.0002).

CONCLUSION:

Household contact DM was associated with an increased risk of RT TB in a cohort in Brazil, lending support to the active screening of household contacts with DM for TB in Brazil.

PMID:
28786800
DOI:
10.5588/ijtld.16.0043
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Ingenta plc
Loading ...
Support Center