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Card Fail Rev. 2016 Nov;2(2):95-101. doi: 10.15420/cfr.2016:16:2.

Impact of Exercise Training on Peak Oxygen Uptake and its Determinants in Heart Failure with Preserved Ejection Fraction.

Author information

College of Nursing and Health Innovation, University of Texas at Arlington, Arlington,Texas, USA.
Technical University Munich,Munich, Germany.
Institute for Exercise and Environmental Medicine,Texas Health Presbyterian Hospital, Dallas.
University of Texas Southwestern Medical Center,Dallas, Texas, USA.
Wake Forest School of MedicineWinston-Salem, North Carolina, USA.
Sport Cardiology, Baker IDI Heart Institute,Melbourne, Victoria, Australia.


Heart failure with preserved ejection (HFpEF) accounts for over 50 % of all HF cases, and the proportion is higher among women and older individuals. A hallmark feature of HFpEF is dyspnoea on exertion and reduced peak aerobic power (VO2peak) secondary to central and peripheral abnormalities that result in reduced oxygen delivery to and/or utilisation by exercising skeletal muscle. The purpose of this brief review is to discuss the role of exercise training to improve VO2peak and the central and peripheral adaptations that reduce symptoms following physical conditioning in patients with HFpEF.


Heart failure with preserved ejection fraction; exercise training; peak aerobic power

Conflict of interest statement

Disclosure: DWK is funded by NIH grants R01AG18915; P30AG12232. MJH is funded by the Moritz Chair in Geriatrics in the College of Nursing and Health Innovation at the University of Texas at Arlington. The remaining authors have no conflicts of interest to declare.

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