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Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00929-17. doi: 10.1128/AAC.00929-17. Print 2017 Oct.

In Vitro Susceptibility to Closthioamide among Clinical and Reference Strains of Neisseria gonorrhoeae.

Author information

1
Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.
2
Centre for Synthetic Biology and Innovation, Department of Life Sciences, Imperial College London, London, United Kingdom.
3
Centre for Synthetic Biology and Innovation, Department of Life Sciences, Imperial College London, London, United Kingdom j.heap@imperial.ac.uk.

Abstract

Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae.

KEYWORDS:

Neisseria gonorrhoeae; antimicrobial agents; closthioamide

PMID:
28784667
PMCID:
PMC5610491
DOI:
10.1128/AAC.00929-17
[Indexed for MEDLINE]
Free PMC Article

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