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Food Res Int. 2017 Sep;99(Pt 1):31-40. doi: 10.1016/j.foodres.2017.07.011. Epub 2017 Jul 4.

Current research, regulation, risk, analytical methods and monitoring results for nicarbazin in chicken meat: A perspective review.

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Universidade Federal do Paraná, Av. Coronel Francisco Heráclito dos Santos, 210, 81531-970 Curitiba, PR, Brazil.
Embrapa Suínos e Aves, BR 153, km 110, 89715-899 Concórdia, SC, Brazil. Electronic address:
Embrapa Suínos e Aves, BR 153, km 110, 89715-899 Concórdia, SC, Brazil.
Ministério da Agricultura, Pecuária e Abastecimento, Laboratório Nacional Agropecuário (Lanagro/RS), Rua João Grumiché, 117, 88102-699 São José, SC, Brazil.


This review presents up-to-date information about current research on nicarbazin, one of the most used anticoccidials in poultry production. The focus is to elucidate regulation concerning nicarbazin, limits for its residues in food, how maximum residue limits in different countries are calculated regarding edible chicken tissues and the possible implications in human health. Analytical methods to extract and quantify this residue, expressed as dinitrocarbanilide (DNC) are presented and discussed, including qualitative screening and quantitative/confirmatory analytical methods. Monitoring results and occurrence of DNC residues in chicken meat are discussed. Additionally, the causes of eventual chicken meat contamination and possible solutions to reduce or eliminate DNC residue in tissues are also presented. The paper concludes with perspectives, the current state of DNC residue analysis and suggestions for future research, especially considering the gap in the study of residue recycling effect due to continuous chicken litter use.


DNC; Food safety; Immunoassay; LC-MS/MS; Litter reuse; Maximum residue limit

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