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Metab Eng. 2017 Sep;43(Pt A):29-36. doi: 10.1016/j.ymben.2017.07.007. Epub 2017 Aug 3.

Co-production of microbial polyhydroxyalkanoates with other chemicals.

Author information

1
Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.
2
Center of Synthetic and Systems Biology, School of Life Science, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China; Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China; MOE Key Lab for Industrial Biocatalysis, Tsinghua University, Beijing 100084, China; Manchester Institute of Biotechnology, University of Manchester, Oxford Road, Manchester M13 9PT, UK. Electronic address: chengq@mail.tsinghua.edu.cn.

Abstract

Engineering microorganisms capable of simultaneously accumulating multiple products are economically attractive for biotechnology. Polyhydroxyalkanoates (PHA) or microbial bioplastics are promising as biodegradable plastics to address environmental concerns resulted from plastic wastes accumulation. Unfortunately, PHA production is still limited and cannot compete with the chemically synthesized plastics due to their high production cost. Efforts have been devoted to reduce PHA production cost by employing PHA co-production with other valuable chemicals. Successful co-productions of PHA have been demonstrated with amino acids, proteins, alcohols, hydrogen, biosurfactants, exopolysaccharides and several fine chemicals. The strategy allows recovering PHA from the cells and other value-added products from the no-cells broths. Numerous successful strategies have been developed for minimizing the substrate cost and improving the product yields. This paper reviews the recent strategies developed in PHA co-production with other compounds, discusses the challenges and prospective during the scale up of the co-production strategies.

KEYWORDS:

Chemicals; Co-production; Metabolic engineering; PHA; PHB; Polyhydroxyalkanoates; Synthetic biology

PMID:
28782693
DOI:
10.1016/j.ymben.2017.07.007
[Indexed for MEDLINE]

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