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Neural Plast. 2017;2017:1546125. doi: 10.1155/2017/1546125. Epub 2017 Jul 11.

Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience.

Author information

1
Axe Neurosciences, Centre de Recherche du CHU de Québec - Université Laval, Québec, QC, Canada.
2
Département de pharmacologie-physiologie, Centre de Recherche du CHU de Sherbrooke, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada.
3
Quebec Pain Research Network, Sherbrooke, QC, Canada.

Abstract

Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for Alzheimer's disease. Stress resilience is a positive outcome that is associated with preserved cognition and healthy aging. Resilience presents psychological and biological characteristics intrinsic to an individual conferring protection against the development of psychopathologies in the face of adversity. How can we promote or improve resilience to chronic stress? Numerous studies have proposed mechanisms that could trigger this desirable process. The roles of enkephalin transmission in the control of pain, physiological functions, like respiration, and affective disorders have been studied for more than 30 years. However, their role in the resilience to chronic stress has received much less attention. This review presents the evidence for an emerging involvement of enkephalin signaling through its two associated opioid receptors, μ opioid peptide receptor and δ opioid peptide receptor, in the natural adaptation to stressful lifestyles.

PMID:
28781901
PMCID:
PMC5525068
DOI:
10.1155/2017/1546125
[Indexed for MEDLINE]
Free PMC Article

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