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J Nutr Metab. 2017;2017:3848201. doi: 10.1155/2017/3848201. Epub 2017 Jul 11.

Inflammatory Markers Are Positively Associated with Serum trans-Fatty Acids in an Adult American Population.

Author information

1
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing, China.
2
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Sciences (IC-UCAS), West Beichen Road, Chaoyang, China.
3
Department of General Surgery, The General Hospital of Chinese People's Armed Police Forces, Beijing, China.
4
Non-Communicable Disease Research Unit, South African Medical Research Council and University of Cape Town, Cape Town, South Africa.

Abstract

BACKGROUND AND AIM:

The relationship between serum trans-fatty acids (TFAs) and systemic inflammation markers is unclear. We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans.

METHODS:

The 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) participants with measured data on hs-CRP and fibrinogen were included. TFAs were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization. Analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters, accounting for the survey design.

RESULTS:

Of the 5446 eligible participants, 46.8% (n = 2550) were men. The mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p = 0.085). After adjustment for age and sex, mean serum TFAs rose with the increasing quarters of hs-CRP and fibrinogen (both p < 0.001). In linear regression models adjusted for age, sex, race, education, marital status, body mass index, and smoking, serum TFAs were an independent predictor of plasma hs-CRP and fibrinogen levels.

CONCLUSION:

A high level of TFAs appears to be a contributor to an unfavourable inflammatory profile. Because serum TFAs concentrations are affected by dietary TFA intake, these data suggest a possible contribution of TFAs intake modulation in the prevention of inflammation-related chronic diseases.

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