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Mol Cells. 2017 Jul 31;40(7):450-456. doi: 10.14348/molcells.2017.0065. Epub 2017 Jul 31.

Implications of Circadian Rhythm in Dopamine and Mood Regulation.

Author information

1
Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
2
Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
3
Department of Brain and Cognitive Sciences, Scranton College, Ewha Womans University, Seoul 03760, Korea.
4
Department of Biomedical Sciences, College of Medicine, Korea University, Seoul 02473, Korea.
5
Korea Brain Research Institute (KBRI), Daegu 41068, Korea.

Abstract

Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-erbα induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.

KEYWORDS:

Parkinson’s disease; REV-ERBα; circadian rhythm; dopaminergic system; mood disorder

PMID:
28780783
PMCID:
PMC5547214
DOI:
10.14348/molcells.2017.0065
[Indexed for MEDLINE]
Free PMC Article

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