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J Crit Care. 2017 Dec;42:207-212. doi: 10.1016/j.jcrc.2017.07.029. Epub 2017 Jul 12.

Hypoxia-inducible-factor-1 in trauma and critical care.

Author information

1
Dept. of Surgery, Morristown Medical Center, United States. Electronic address: dorian.bogdanovski@atlantichealth.org.
2
Dept. of Surgery, Morristown Medical Center, United States. Electronic address: Louis.difazio@atlantichealth.org.
3
Rutgers- New Jersey Medical School, United States. Electronic address: ana.bogdanovski@gmail.com.
4
Dept. of Surgery, Rutgers-New Jersey Medical School, United States. Electronic address: csokaba@njms.rutgers.edu.
5
Dept. of Surgery, Morristown Medical Center, United States. Electronic address: garrettbjordan@gmail.com.
6
Dept. of Surgery, Morristown Medical Center, United States. Electronic address: Elina.Paul@quinnipiac.edu.
7
Dept. of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. Electronic address: lucaant@gmail.com.
8
Dept. of Surgery, Morristown Medical Center, United States. Electronic address: stefanie.pilip@atlantichealth.org.
9
Dept. of Surgery, Morristown Medical Center, United States; Dept. of Surgery, Rutgers-New Jersey Medical School, United States. Electronic address: zoltan.nemeth@atlantichealth.org.

Abstract

HIF-1 is a ubiquitous signaling molecule constantly expressed by the body, but is degraded during normoxic conditions. In hypoxic conditions, it persists and is active. Hypoxia is often associated with trauma due to interrupted blood flow, inflammation or other reasons, causing HIF-1 to be active in signaling and recovery. In this review, the function of HIF-1 is examined, as well as its clinical significance with regard to trauma and critical care. Using this information, we then identify potential points of treatment and intervention.

KEYWORDS:

HIF-1; Hypoxia; Inflammation; Ischemia; Sepsis

PMID:
28779702
DOI:
10.1016/j.jcrc.2017.07.029
[Indexed for MEDLINE]

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