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Trends Genet. 2017 Oct;33(10):660-662. doi: 10.1016/j.tig.2017.07.005. Epub 2017 Aug 1.

On the Origin of lncRNAs: Missing Link Found.

Author information

1
Linda Crnic Institute for Down Syndrome and Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Boulder, CO 80203, USA. Electronic address: joaquin.espinosa@ucdenver.edu.

Abstract

Non-coding (nc)RNAs known as enhancer-derived RNAs (eRNAs) and as long ncRNAs (lncRNAs) have received much attention, but their true functional specialization and evolutionary origins remain obscure. The recent characterization of Bloodlinc, an eRNA derived from a super-enhancer that also functions as a lncRNA, suggests that lncRNAs can evolve from eRNAs.

KEYWORDS:

CTCF; chromatin loop; eRNA; lncRNA; noncoding RNA; superenhancer; topological activation domain

PMID:
28778681
PMCID:
PMC5610073
DOI:
10.1016/j.tig.2017.07.005
[Indexed for MEDLINE]
Free PMC Article

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