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Allergol Int. 2018 Apr;67(2):209-216. doi: 10.1016/j.alit.2017.07.007. Epub 2017 Aug 1.

Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians: A multicenter, randomized, parallel-group, delayed-start design study.

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Department of Pediatrics, Shimoshizu National Hospital, Chiba, Japan.
Department of Pediatrics, Eastern Chiba Medical Center, Chiba, Japan; Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address:
Allergy Center, Mie National Hospital, Mie, Japan.
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
Allergy Center, Mie National Hospital, Mie, Japan; Department of Education for Childcare, Faculty of Child Studies, Tokyo Kasei University, Saitama, Japan.



Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL).


We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. The early-start group received rOIT for 3 months, while the late-start group continued the egg elimination diet (control). In the next stage, both groups received OIT until all participants had finished 12 months of maintenance OIT.


The ratio of the participants in whom an increase of the TD was achieved in the first stage was significantly higher in the early-start group (87.0%), than in the late-start group (22.7%). The QOL of the guardians in the early-start group significantly improved after the first stage (65.2%), in comparison to the late-start group (31.8%). During 12 months of rOIT, the serum ovomucoid-specific IgE levels, the percentage of CD203c+ basophils upon stimulation with egg white, and the wheal size to egg white were decreased, while the serum ovomucoid-specific IgG4 levels were increased. However, approximately 80% of the participants in the early-start group showed an allergic reaction during the first stage of the study, whereas none of the patients in the late-start group experienced an allergic reaction.


rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment.


Desensitization; Food allergy; Guardians; Oral immunotherapy; Quality of life

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