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J Alzheimers Dis. 2017;59(4):1459-1470. doi: 10.3233/JAD-170123.

Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial.

Author information

1
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
2
Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
3
Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
4
Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
5
Department of Biosciences, University of Helsinki, Helsinki, Finland.
6
Institute of Gerontology, School of Health and Welfare, Aging Research Network - Jönköping (ARN-J), Jönköping University, Jönköping, Sweden.
7
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
8
Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.
9
Oulu City Hospital, Oulu, Finland.
10
Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland.
11
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
12
Hospital District of North Karelia, Joensuu, Finland.
13
Institute of Occupational Health, Helsinki, Finland.
14
Department of General Internal Medicine, Geriatrics and Integrative Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
15
Departments of Pharmacology and Neurology, Boston University School of Medicine, Boston, MA, USA.
16
University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland.
17
Department of Public Health, HJELT Institute, University of Helsinki, Helsinki, Finland.
18
University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.
19
South Ostrobothnia Central Hospital, Seinäjoki, Finland.
20
Department of Clinical Neurosciences and Preventive Medicine, Danube-University Krems, Krems, Austria.
21
Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
22
Dasman Diabetes Institute, Kuwait City, Kuwait.
23
Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland.
24
Department of Geriatrics, Karolinska University Hospital, Stockholm, Sweden.

Abstract

Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals.

KEYWORDS:

Cognition; dementia; lifestyle; multidomain intervention; telomere length

PMID:
28777749
PMCID:
PMC5611796
DOI:
10.3233/JAD-170123
[Indexed for MEDLINE]
Free PMC Article

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