Send to

Choose Destination
J Epilepsy Res. 2017 Jun 30;7(1):45-49. doi: 10.14581/jer.17008. eCollection 2017 Jun.

Ketogenic Diet for the Management of Epilepsy Associated with Tuberous Sclerosis Complex in Children.

Author information

Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
Division of Dietetics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
Epilepsy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Division of Pediatric Neurology, Epilepsy Research Institute, Severance Children's Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.



In the present study, we reviewed the outcome of ketogenic diet (KD) use for the management of epilepsy in children with tuberous sclerosis complex (TSC).


A total of 12 children with intractable epilepsy associated with TSC who were treated with KD at our hospital between March 1, 2008 and February 28, 2015 were retrospectively enrolled.


The mean age at the time of KD initiation was 73.1 ± 38.0 months. Patients were medically refractory to a mean of 4.8 ± 1.7 antiepileptic drugs. Nine patients (75.0%) had a history of infantile spasms. At 3 months after KD initiation, 10 patients (83.3%) had > 50% seizure reduction. Moreover, 7 patients (58.3%) exhibited qualitative improvements in cognition and behavior after KD initiation, as reported by caregivers/parents. The mean duration of dietary therapy was 14.8 ± 12.8 months. Half of the patients in this study eventually underwent epilepsy surgery due to persistent seizures or seizure relapse.


KD is an important non-pharmacological treatment option for patients with intractable epilepsy associated with TSC. KD may improve cognition and behavior in addition to reducing seizure frequency.


Children; Epilepsy; Ketogenic diet; Tuberous sclerosis complex

Conflict of interest statement

Conflicts of Interest The authors have no financial conflicts of interest.

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center