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Science. 2017 Aug 25;357(6353). pii: eaal2379. doi: 10.1126/science.aal2379. Epub 2017 Aug 3.

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology.

Author information

1
Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), 69121 Heidelberg, Germany. augustin@angiogenese.de gykoh@kaist.ac.kr.
2
Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim (CBTM), Heidelberg University, D-67167 Mannheim, Germany.
3
Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea. augustin@angiogenese.de gykoh@kaist.ac.kr.
4
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.

Abstract

Blood vessels form one of the body's largest surfaces, serving as a critical interface between the circulation and the different organ environments. They thereby exert gatekeeper functions on tissue homeostasis and adaptation to pathologic challenge. Vascular control of the tissue microenvironment is indispensable in development, hemostasis, inflammation, and metabolism, as well as in cancer and metastasis. This multitude of vascular functions is mediated by organ-specifically differentiated endothelial cells (ECs), whose cellular and molecular heterogeneity has long been recognized. Yet distinct organotypic functional attributes and the molecular mechanisms controlling EC differentiation and vascular bed-specific functions have only become known in recent years. Considering the involvement of vascular dysfunction in numerous chronic and life-threatening diseases, a better molecular understanding of organotypic vasculatures may pave the way toward novel angiotargeted treatments to cure hitherto intractable diseases. This Review summarizes recent progress in the understanding of organotypic vascular differentiation and function.

PMID:
28775214
DOI:
10.1126/science.aal2379
[Indexed for MEDLINE]

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