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Clin Neuropsychol. 2018 Jul;32(5):922-936. doi: 10.1080/13854046.2017.1361473. Epub 2017 Aug 4.

Prospective memory impairment in multiple sclerosis: a review.

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a Department of Psychology , Université du Québec à Montréal , Montreal , Canada.
b Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) , Montreal , Canada.
c Neurology Service , Hôpital du Sacré-Coeur de Montréal , Montreal , Canada.



Multiple sclerosis (MS) is a progressive disease of the central nervous system affecting information processing speed, episodic memory, attention, and executive functions. MS patients also often report prospective memory (PM) failures that directly impact their functional autonomy, including professional and social life. The purpose of this paper was to review the literature concerning the assessment and remediation of PM deficits in MS.


The literature pertaining to PM impairment in MS was carefully reviewed using PubMed, PsyINFO, and Google Scholar, as well as cross-references from the articles published on this topic. Since PM rehabilitation in MS patients is still in its infancy, this review mainly focuses on studies that have directly assessed PM through various measures including questionnaires, standardized clinical tests, and experimental procedures.


This literature review confirms the presence of PM deficits in MS patients, even in the early stages of the disease. A further need for controlled studies on PM assessment and PM interventions in patients with MS is stressed.


Prospective memory; clinical assessment; multiple sclerosis

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