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Materials (Basel). 2016 Nov 23;9(11). pii: E954. doi: 10.3390/ma9110954.

Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration.

Author information

1
Department of Dentistry, School of Medicine, Korea University, Seoul 02841, Korea. jinchol09@hanmail.net.
2
Department of Prosthodontics, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. 0228dmqls@hanmail.net.
3
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea. sen0223@gmail.com.
4
School of Dentistry, Pusan National University, Yangsan 50612, Korea. annasoyunkim@gmail.com.
5
Tissue Biotech Institute, Cowellmedi Co., Ltd., Busan 46986, Korea. ckh@cowellmedi.com.
6
Department of Prosthodontics, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. won9180@hanmail.net.
7
Department of Prosthodontics, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. say0739@daum.net.
8
Department of Dentistry, School of Medicine, Korea University, Seoul 02841, Korea. koprosth@unitel.co.kr.
9
Department of Prosthodontics, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea. neoplasia96@hanmail.net.

Abstract

This study was undertaken to investigate the effect of loading rhBMP-2 onto biphasic calcium phosphate (BCP) and calcium pyrophosphate (CPP) on bone regeneration, and to examine the efficacies of BCP and CPP as rhBMP-2 carriers. Specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups; BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP were prepared as discs, which were treated with rhBMP-2 and collagen. Physical and biological features were investigated using in-vitro and in-vivo tests. New bone area percentages (%) in the BCP/BMP and CPP/BMP groups were significantly greater than in the BCP and CPP groups. At weeks 4 and 8 post-implantation, CPP/BMP showed the most new bone growth. Within the limitations of this study, treatment of BCP and CPP with rhBMP-2 significantly enhanced bone regeneration. CPP was found to be a suitable carrier for rhBMP-2.

KEYWORDS:

alloplast; biphasic calcium phosphate; bone substitutes; calcium pyrophosphate; rhBMP-2

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