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Materials (Basel). 2017 Apr 14;10(4). pii: E411. doi: 10.3390/ma10040411.

Preparation and Characterization of Thermoresponsive Poly(N-isopropylacrylamide-co-acrylic acid)-Grafted Hollow Fe₃O₄/SiO₂ Microspheres with Surface Holes for BSA Release.

Author information

1
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. zhaoyujing_zibo@126.com.
2
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. zm1992123@sina.com.
3
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. zkq0908@126.com.
4
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. imxhhe@scut.edu.cn.
5
Department of Otorhinolaryngology Head & Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China. min_qiang_x@hotmail.com.
6
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. psxyfu@scut.edu.cn.

Abstract

Thermoresponsive P(NIPAM-AA)/Fe₃O₄/SiO₂ microspheres with surface holes serving as carriers were prepared using p-Fe₃O₄/SiO₂ microspheres with a thermoresponsive copolymer. The p-Fe₃O₄/SiO₂ microspheres was obtained using a modified Pickering method and chemical etching. The surface pore size of p-Fe₃O₄/SiO₂ microspheres was in the range of 18.3 nm~37.2 nm and the cavity size was approximately 60 nm, which are suitable for loading and transporting biological macromolecules. P(NIPAM-AA) was synthesized inside and outside of the p-Fe₃O₄/SiO₂ microspheres via atom transfer radical polymerization of NIPAM, MBA and AA. The volume phase transition temperature (VPTT) of the specifically designed P(NIPAM-AA)/Fe₃O₄/SiO₂ microspheres was 42.5 °C. The saturation magnetization of P(NIPAM-AA)/Fe₃O₄/SiO₂ microspheres was 72.7 emu/g. The P(NIPAM-AA)/Fe₃O₄/SiO₂ microspheres were used as carriers to study the loading and release behavior of BSA. This microsphere system shows potential for the loading of proteins as a drug delivery platform.

KEYWORDS:

Fe3O4/SiO2 hollow microspheres; P(NIPAM-AA); drug release; holes

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