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Curr Opin Biotechnol. 2018 Feb;49:16-22. doi: 10.1016/j.copbio.2017.07.003. Epub 2017 Jul 31.

Synthetic genetic circuits in crop plants.

Author information

1
University of Washington, Department of Electrical Engineering, Seattle, WA, USA.
2
University of Washington, Department of Biology, Seattle, WA, USA. Electronic address: jn7@uw.edu.

Abstract

The love affair between crop breeding and genetics began over a century ago and has continued unabated, from mass selection programs to targeted genome modifications. Synthetic genetic circuits, a recent development, are combinations of regulatory and coding DNA introduced into a crop plant to achieve a desired function. Genetic circuits could accelerate crop improvement, allowing complex traits to be rationally designed and requisite DNA parts delivered directly into a genome of interest. However, there is not yet a standardized pipeline from exploratory laboratory testing to crop trials, and bringing transgenic products to market remains a considerable barrier. We highlight successes so far and future developments necessary to make genetic circuits a viable crop improvement technology over this century.

PMID:
28772191
PMCID:
PMC6007868
[Available on 2019-02-01]
DOI:
10.1016/j.copbio.2017.07.003
[Indexed for MEDLINE]

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