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Am J Reprod Immunol. 2017 Oct;78(4). doi: 10.1111/aji.12733. Epub 2017 Aug 3.

Vitamin D deficiency in an Italian cohort of infertile women.

Author information

1
Rheumatology, Allergology and Clinical Immunology, Department of "Medicina dei Sistemi", University of Rome Tor Vergata, Rome, Italy.
2
Department of Medicine 'B', Tel-Aviv University, Tel-Aviv, Israel.
3
Zabludowicz center for Autoimmune Diseases, Tel-Aviv University, Tel-Aviv, Israel.
4
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
5
Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Rome, Italy.
6
Department of Laboratory Medicine, Tor Vergata University Hospital of Rome, Rome, Italy.
7
Polymedical Center for Prevention of Recurrent Spontaneous Abortion, Rome, Italy.

Abstract

PROBLEM:

The purpose of this study was to explore whether vitamin D might be a marker of female primary infertility in association with the presence of autoimmune diseases (ADs).

METHODS:

The study was a cross-sectional descriptive study in consecutive outpatients of the Polymedical Center for Prevention of Recurrent Spontaneous Abortion (RSA), in Rome, Italy. Women were eligible if they received a diagnosis of primary infertility or RSA. Serum vitamin D, calcium, and PTH were analyzed.

RESULTS:

Women with primary infertility (n=70) or RSA/non-infertile (n=105) were enrolled; controls (n=250) were included. Infertile women presented lower vitamin D (P=0.03) and higher prevalence of AD (P=0.007) than non-infertile women. In the multivariate analysis, the presence of ADs is associated with higher odds of infertility (OR=2.2), while normal vitamin D was a protective factor (OR=0.9).

CONCLUSION:

We described that having vitamin D deficiency and suffering from an AD are independent risk factors for women primary infertility. Supplementation of vitamin D might be useful for pregnancy outcome.

KEYWORDS:

autoimmunity; infertility; recurrent abortions; thyroid; vitamin D

PMID:
28771916
DOI:
10.1111/aji.12733
[Indexed for MEDLINE]

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