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J Neurol. 2017 Sep;264(9):1945-1955. doi: 10.1007/s00415-017-8583-z. Epub 2017 Aug 2.

MOG antibody-related disorders: common features and uncommon presentations.

Author information

1
Service de Neurologie A, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677, Bron, France. alvaro.cobo-calvo@chu-lyon.fr.
2
Lyon's Neuroscience Research Center, U1028 Inserm, UMR5292 Cnrs, FLUID Team, 69008, Lyon, France. alvaro.cobo-calvo@chu-lyon.fr.
3
Lyon's Neuroscience Research Center, U1028 Inserm, UMR5292 Cnrs, FLUID Team, 69008, Lyon, France.
4
Hôpital Femme Mère Enfant, Neurologie pédiatrique, Hospices Civils de Lyon, 69677, Bron, France.
5
Service de Neurologie A, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677, Bron, France.
6
Service de neuropédiatrie, Hôpital Kremlin-Bicêtre, 78, rue du Général-Leclerc, 94270, Le Kremlin-Bicêtre, France.

Abstract

Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) have been reported in acute demyelinating encephalomyelitis (ADEM), optic neuritis (ON), and neuromyelitis optica spectrum disorders (NMOSD) in adults and pediatrics. We aimed to delineate the common features of MOG-Ab-related disorders in children and adults, and report uncommon presentations. Twenty-seven consecutive pediatric and adult patients testing positive for MOG-Ab, with a minimum follow-up of 6 months, were included. Comprehensive epidemiological, clinical, radiological, and laboratory data were retrospectively analyzed. Additionally, we compared radiological features between ADEM MOG-Ab-positive patients, and a group of ADEM MOG-Ab-negative ones, recruited during the same period. Among the whole cohort, 13 (48.1%) were pediatric, and 14 (51.9%) were female. MOG-Ab-related disorders comprised eight ADEM, eight ON, five isolated myelitis, four with NMOSD and two patients with multiple sclerosis, at last follow-up. After a median follow-up of 17.8 months, 11 (40.7%) patients presented a relapse. The most frequent clinical phenotype at onset was encephalopathy in pediatrics (53.9%) and myelitis in adults (50%) (p = 0.013). There were no other differences between both groups. When comparing ADEM MOG-Ab positive and negative patients, bilateral thalamic lesions were more often found in the positive group (p = 0.010). Unusual presentations were identified in three patients: patchy spinal cord gadolinium-enhancing lesions, an associated teratoma, and one presented with status epilepticus. MOG-Ab-related disorders shared common clinical and prognostic features, but encompass a spectrum wider than recently reported.

KEYWORDS:

Aquaporin-4 antibodies; MOG antibodies; Multiple sclerosis; Neuromyelitis optica

PMID:
28770374
DOI:
10.1007/s00415-017-8583-z
[Indexed for MEDLINE]

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