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J Diabetes Res. 2017;2017:5850879. doi: 10.1155/2017/5850879. Epub 2017 Jul 9.

The Association between Type 2 Diabetes Mellitus and Thyroid Cancer.

Seo YG1, Choi HC2, An AR3, Park DJ4, Park YJ4, Lee KE5, Park SK6,7,8, Hwang Y6,7,8, Cho B3,9,10.

Author information

1
Department of Family Medicine, Hallym University Sacred Heart Hospital, Anyang, Gyeonggi-do 14068, Republic of Korea.
2
Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 03080, Republic of Korea.
3
Department of Family Medicine, Center for Health Promotion and Optimal Aging, Health Promotion Center for Cancer Survivor, Seoul National University Hospital, Seoul 03080, Republic of Korea.
4
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
5
Department of Surgery, Seoul National University Hospital & College of Medicine, Seoul 03080, Republic of Korea.
6
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
7
Department of Biomedical Science, Seoul National University Graduate School, Seoul 03080, Republic of Korea.
8
Cancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
9
Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Gyeonggi-do 16229, Republic of Korea.
10
Institute on Aging, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Abstract

AIM:

The incidence of thyroid cancer is increasing worldwide. The prevalence of type 2 diabetes mellitus (T2DM) is also increasing. Therefore, we aimed to analyze the effect of T2DM on thyroid cancer.

METHODS:

A case-control study was performed. A total of 415 healthy controls with thyroid ultrasound screening and physician consultation were selected from the Thyroid Cancer Longitudinal Study (T-CALOS). Among patients with thyroid cancer who were enrolled in T-CALOS, 415 patients were matched to the control group according to age and sex. We assessed the effects of T2DM, T2DM duration, and T2DM medication on thyroid cancer.

RESULTS:

Women with T2DM had lower odds of thyroid cancer than women without T2DM (odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.20-0.81). Individuals receiving T2DM medication had higher odds of thyroid cancer compared to those without T2DM medication (OR: 5.21, 95% CI: 1.58-17.15). Individuals with T2DM duration <6 years had lower odds of thyroid cancer compared to those without T2DM (OR: 0.58, 95% CI: 0.34-0.97).

CONCLUSIONS:

Individuals with early T2DM are presumed to have a low incidence of thyroid cancer, and this effect seems to last up to 6 years after diagnosis of T2DM.

PMID:
28770232
PMCID:
PMC5523441
DOI:
10.1155/2017/5850879
[Indexed for MEDLINE]
Free PMC Article

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