Format

Send to

Choose Destination
Front Pharmacol. 2017 Jul 18;8:472. doi: 10.3389/fphar.2017.00472. eCollection 2017.

Cellular and Molecular Targets of Menthol Actions.

Author information

1
Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates UniversityAl Ain, United Arab Emirates.
2
Department of Basic Medical Sciences, College of Medicine, Qatar UniversityDoha, Qatar.
3
Department of Biological Sciences, Schmid College of Science and Technology, Chapman UniversityOrange, CA, United States.
4
Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates UniversityAl Ain, United Arab Emirates.
5
Department of Health Sciences, College of Natural and Health Sciences, Zayed UniversityAbu Dhabi, United Arab Emirates.

Abstract

Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.

KEYWORDS:

TRP channels; ligand-gated ion channels; menthol; monoterpenes; voltage-gated ion channels

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center