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Cell Rep. 2017 Aug 1;20(5):1061-1072. doi: 10.1016/j.celrep.2017.07.022.

Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage.

Author information

1
State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Cell Biology and Genetics, School of Preclinical Medicine, Guangxi Medical University, Nanning 530021, China.
2
Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
3
Department of Computer Science, University of California, Irvine, Irvine, CA 92697, USA.
4
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
5
State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
6
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
7
Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Medicine, Division of Endocrinology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA; Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: bogi@uci.edu.

Abstract

The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.

KEYWORDS:

DNA damage; aging; cell cycle; circadian clock; metabolism; skin; time-restricted feeding

PMID:
28768192
PMCID:
PMC5600321
DOI:
10.1016/j.celrep.2017.07.022
[Indexed for MEDLINE]
Free PMC Article

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