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Am J Gastroenterol. 2017 Aug;112(8):1265-1266. doi: 10.1038/ajg.2017.185.

Editorial: The Effect of Bias on Estimation of Improved Survival After Diagnosis of Barrett's Esophagus.

Author information

1
Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA.
2
Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

Adjustments for lead and length time bias has been used when examining apparent survival advantages from screening procedures. However, these estimates depend on several assumptions and are modeled from malignancies that are fairly common and large cohorts are available. In smaller retrospective cohorts, adjustments themselves may be based on estimates that may not be biological nor statistically accurate, which can lead to divergent results as has been found in several recent studies of screening in Barrett's esophagus. Only a prospective randomized controlled trial can really determine the benefit though this may not feasible.

PMID:
28766563
PMCID:
PMC5574169
DOI:
10.1038/ajg.2017.185
[Indexed for MEDLINE]
Free PMC Article

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