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J Bone Miner Metab. 2018 Jul;36(4):470-477. doi: 10.1007/s00774-017-0857-0. Epub 2017 Aug 1.

Low serum osteocalcin concentration is associated with incident type 2 diabetes mellitus in Japanese women.

Author information

1
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
2
Department of Geriatric Medicine, School of Medicine, International University of Health and Welfare, Chiba, Japan.
3
Research Institute and Practice for Involutional Diseases, Nagano, Japan.
4
Public Health Research Foundation, Tokyo, Japan.
5
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
6
Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.
7
Division of Nutritional Physiology, Kagawa Nutrition University, Saitama, Japan.
8
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. sinoue07@gmail.com.
9
Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashi-ku, Tokyo, Japan. sinoue07@gmail.com.
10
Research Center for Genomic Medicine, Saitama Medical School, Saitama, Japan. sinoue07@gmail.com.

Abstract

Increasing evidence suggests that osteocalcin is involved in the regulation of glucose homeostasis. However, the relationship between serum osteocalcin levels and risk of incident type 2 diabetes mellitus is not clear. The objective of this study is to investigate whether serum osteocalcin levels are associated with the risk of incident type 2 diabetes mellitus. This study included 1691 Japanese postmenopausal women, 61 incident diabetes cases, and 1630 non-diabetic control subjects in the observation period. Baseline concentrations of intact osteocalcin, HbA1c, bone-specific alkaline phosphatase, adiponectin, leptin, urinary N-telopeptides were assessed. Serum osteocalcin levels were significantly correlated with HbA1c levels among 1691 Japanese postmenopausal women (R = -0.12, P < 0.0001). In receiver operating characteristic curve analysis, the optimal cut-off levels for serum osteocalcin to predict the development of type 2 diabetes mellitus was 6.1 ng/mL. The group with baseline osteocalcin levels <6.1 ng/mL showed a significantly higher risk for developing diabetes than the group with baseline osteocalcin levels >6.1 ng/mL (log-rank test, P  <  0.0001) during the mean observation period (7.6 ± 6.1 years; mean ± SD). In multiple Cox proportional hazard analysis, osteocalcin levels were significantly associated with development of type 2 diabetes mellitus during the observation period. Our results indicate that a decrease in serum osteocalcin levels is associated with future development of type 2 diabetes mellitus independent of conventional risk factors in Japanese postmenopausal women.

KEYWORDS:

HbA1c; Osteocalcin; Osteoporosis; Type 2 diabetes mellitus

PMID:
28766135
DOI:
10.1007/s00774-017-0857-0
[Indexed for MEDLINE]

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