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Cancer Epidemiol Biomarkers Prev. 2017 Aug;26(8):1349-1351. doi: 10.1158/1055-9965.EPI-17-0075.

Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium.

Author information

1
Department of Biology, University of Pisa, Pisa, Italy.
2
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
3
Digestive and Liver Disease Unit, S. Andrea Hospital, "Sapienza" University of Rome, Rome, Italy.
4
Pancreatic and Digestive Endocrine Surgery, Department of Surgery, Oncology and Gastroenterology -DiSCOG, University of Padova, Padua, Italy.
5
Institute of Translational Medicine, Cancer Research UK Liverpool Cancer Trials Unit, Liverpool, United Kingdom.
6
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
7
Division of Gastroenterology and Research Laboratory, Department of Surgery, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
8
ARC-NET: Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.
9
Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
10
Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
11
Department of Medicine - DIMED, University of Padova, Padua, Italy.
12
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom.
13
Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.
14
Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, University of Pisa, Pisa, Italy.
15
Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
16
University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
17
The Pancreas Institute, Department of Surgery, University and Hospital Trust of Verona, Verona, Italy.
18
Blood Transfusion Service, Azienda Ospedaliero Universitaria Meyer, Florence, Italy.
19
Department of Laboratory Medicine, University-Hospital of Padova, Padua, Italy.
20
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. f.canzian@dkfz.de.

Abstract

Background: Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci.Methods: To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. We genotyped the selected SNPs (rs16944, rs1052536, rs1059293, rs1136410, rs1143634, rs2069762, rs2236302, rs2387632, rs3212961, rs3734299, rs3803258, rs4962081, rs7234941, rs7243091, rs12957119, and rs1800629) in 344 PNET sporadic cases and 2,721 controls in the context of the PANcreatic Disease ReseArch (PANDoRA) consortium.Results: After correction for multiple testing, we did not observe any statistically significant association between the SNPs and PNET risk. We also used three online bioinformatic tools (HaploReg, RegulomeDB, and GTEx) to predict a possible functional role of the SNPs, but we did not observe any clear indication.Conclusions: None of the selected SNPs were convincingly associated with PNET risk in the PANDoRA consortium.Impact: We can exclude a major role of the selected polymorphisms in PNET etiology, and this highlights the need for replication of epidemiologic findings in independent populations, especially in rare diseases such as PNETs. Cancer Epidemiol Biomarkers Prev; 26(8); 1349-51. ©2017 AACR.

PMID:
28765340
DOI:
10.1158/1055-9965.EPI-17-0075
[Indexed for MEDLINE]
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