Send to

Choose Destination
Can J Physiol Pharmacol. 2018 Jan;96(1):76-79. doi: 10.1139/cjpp-2017-0193. Epub 2017 Aug 1.

Age-related testosterone declines can be detected in men's fingernails.

Author information

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.


Testosterone plays multiple roles in the regulation of development, physiology, reproduction, and behavior. Age-related testosterone declines are expected in the population. However, measuring circulating testosterone is especially challenging because concentrations are labile, responding to social situations and challenges. Matrices that integrate long-term testosterone levels are therefore valuable as biomarkers of endogenous levels as well as chronic exposures. Here, we report on a simple method to extract and measure accumulated testosterone from human fingernails using commercial enzyme immunoassay kits. Furthermore, we demonstrate known human testosterone sex and age trends. Our method is especially useful for quantifying testosterone in men's nails, where a small amount of matrix is required. Thus, this approach is a potential tool for biomonitoring endogenous as well as exogenous testosterone exposure. We suggest considering nails as an alternative matrix for quantifying other steroids as well.


biomonitoring; endogenous testosterone levels; fingernails; integrated matrices; matrices intégrées; non effractif; noninvasive; ongles; surveillance biologique; taux de testostérone endogène

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center