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Vet Comp Orthop Traumatol. 2017 Sep 12;30(5):318-323. doi: 10.3415/VCOT-17-02-0020. Epub 2017 Aug 1.

Efficacy of an oral nutraceutical for the treatment of canine osteoarthritis. A double-blind, randomized, placebo-controlled prospective clinical trial.

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Ruth M. Scott, DVM, University of Minnesota, College of Veterinary Medicine, 1352 Boyd Ave., St. Paul, MN 55108, United States, Phone: + 1 612 626 8387, Fax: + 1 612 626 3569, E-mail:, Received: February 5, 2017, Accepted: April 19, 2017, Epub ahead of print: August 1, 2017.



To assess the safety and efficacy of an orally administered nutraceutical (Glu/CS+; + for additional ingredient) for the treatment of clinical osteoarthritis (OA) in dogs.


In this double-blind, randomized, placebo-controlled clinical trial, client-owned dogs with clinical signs of OA in one or more joints were assigned to a Glu/CS+ (n = 30) or placebo (n = 30) group. Dogs were administered Glu/CS+ or placebo orally and wore an activity monitor (AM) continuously throughout a 97 day study period. Prior to the initiation of the treatment, seven days of baseline activity was collected. On days -7, 30, 60 and 90 of the study, owners completed a patient assessment form (Canine Brief Pain Inventory). Data between groups were compared.


No serious adverse events were reported. No difference was found between groups when evaluating daily activity counts during the seven-day pre-treatment period and the 90-day treatment period. Owner assessment (pain interference and pain severity scores) improved over the 90-day treatment period for both groups, however no difference was found between treatment groups.


Treatment with oral Glu/CS+ for a 90 day treatment period when compared to placebo treatment did not result in a significant increase in activity counts in dogs with clinical OA. However, owner assessment scores similarly improved throughout the study period for dogs in both groups, suggesting a caregiver placebo effect in this outcome measure.


Dogs; activity monitor; chondroitin; glucosamine; osteoarthritis

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