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J Nat Prod. 2017 Aug 25;80(8):2353-2359. doi: 10.1021/acs.jnatprod.7b00395. Epub 2017 Aug 1.

Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice.

Author information

1
Department of Endocrinology and Internal Medicine, Aarhus University Hospital , Tage-Hansens Gade 2, 8000 Aarhus C, Denmark.
2
Department of Clinical Medicine, Aarhus University , Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark.
3
The Danish Diabetes Academy, Odense University Hospital , Sdr. Boulevard 29, 5000 Odense C, Denmark.
4
MR Research Centre, Department of Clinical Medicine, Aarhus University Hospital , Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Abstract

Daily coffee consumption is inversely associated with risk of type-2 diabetes (T2D). Cafestol, a bioactive substance in coffee, increases glucose-stimulated insulin secretion in vitro and increases glucose uptake in human skeletal muscle cells. We hypothesized that cafestol can postpone development of T2D in KKAy mice. Forty-seven male KKAy mice were randomized to consume chow supplemented daily with either 1.1 (high), 0.4 (low), or 0 (control) mg of cafestol for 10 weeks. We collected blood samples for fasting glucose, glucagon, and insulin as well as liver, muscle, and fat tissues for gene expression analysis. We isolated islets of Langerhans and measured insulin secretory capacity. After 10 weeks of intervention, fasting plasma glucose was 28-30% lower in cafestol groups compared with the control group (p < 0.01). Fasting glucagon was 20% lower and insulin sensitivity improved by 42% in the high-cafestol group (p < 0.05). Cafestol increased insulin secretion from isolated islets by 75-87% compared to the control group (p < 0.001). Our results show that cafestol possesses antidiabetic properties in KKAy mice. Consequently, cafestol may contribute to the reduced risk of developing T2D in coffee consumers and has a potential role as an antidiabetic drug.

PMID:
28763212
DOI:
10.1021/acs.jnatprod.7b00395
[Indexed for MEDLINE]

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