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J Cardiovasc Transl Res. 2017 Dec;10(5-6):480-488. doi: 10.1007/s12265-017-9763-z. Epub 2017 Jul 31.

In Vitro Mechanical Property Evaluation of Chitosan-Based Hydrogels Intended for Vascular Graft Development.

Author information

1
University Bordeaux, 33000, Bordeaux, France.
2
INSERM, Bioingénierie tissulaire, U1026, 33000, Bordeaux, France.
3
CHU de Bordeaux, 33000, Bordeaux, France.
4
University Lyon, Université Lyon 1, Ingénierie des Matériaux Polymères (IMP), CNRS UMR 5223, 69622, Villeurbanne Cedex, France.
5
Rescoll, 8 Allée Geoffroy Saint-Hilaire, 33600, Pessac, France.
6
CHU de Bordeaux, CIC 1401, 33000, Bordeaux, France.
7
INSERM, U1148, Laboratoire de recherche vasculaire translationnelle, 75000, Paris, France.
8
University Paris Diderot, Sorbonne Paris Cité, 75000, Paris, France.
9
University Bordeaux, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.
10
INSERM, Bioingénierie tissulaire, U1026, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.
11
CHU de Bordeaux, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.
12
CHU de Bordeaux, CIC 1401, 33000, Bordeaux, France. laurence.bordenave@chu-bordeaux.fr.

Abstract

Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be produced and shaped to provide a novel scaffold for vascular tissue engineering. The goal of this study was to evaluate in vitro the mechanical properties of a novel chitosan formulation to assess its potential for this scaffold. Two chitosan-based hydrogel tubes were produced by modulating chitosan concentration. Based on the standard ISO 7198:1998, the hydrogel tubes were characterized in vitro in terms of suture retention strength, tensile strength, compliance, and burst pressure. By increasing chitosan concentration, suture retention value increased to reach 1.1 N; average burst strength and elastic moduli also increased significantly. The compliance seemed to exhibit a low value for chitosan tubes of high concentration. By modulating chitosan concentration, we produced scaffolds with suitable mechanical properties to be implanted in vivo and withstand physiological blood pressures.

KEYWORDS:

Chitosan; Hydrogels; In vitro; Mechanical properties; Vascular graft development

PMID:
28762052
DOI:
10.1007/s12265-017-9763-z
[Indexed for MEDLINE]

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