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Respir Med Case Rep. 2017 May 30;22:7-10. doi: 10.1016/j.rmcr.2017.05.010. eCollection 2017.

EGFR or PD-L1 decision for first line therapy in a case series of EGFR positive and PD-L1 >50.

Author information

1
Pulmonary Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
2
Oncology Department, University General Hospital of Larissa, Larissa, Greece.
3
Department of Respiratory and Critical Care Medicine, Changhai Hospital, The Second Military Medical University, Shanghai, China.
4
Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
5
Sana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof" Clinics, University of Erlangen, Hof, Germany.

Abstract

Targeted therapies are on the market for the past five years and recently pembrolizumab was approved as first line treatment for patients with PD-L1 >50%. We present three cases of patients which had epidermal growth factor receptor positive expression and programmed death-ligand 1 (PD-L1), PD-L1 >50% overexpression.

KEYWORDS:

Adenocarcinoma; Anaplastic lymphoma kinase; Epidermal growth factor; NSCLC; Programmed death-ligand 1

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