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Neural Regen Res. 2017 Jun;12(6):953-958. doi: 10.4103/1673-5374.208590.

Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis.

Author information

1
Department of Orthopedics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
2
Department of Public Security Technology, Railway Police College, Zhengzhou, Henan Province, China.
3
Department of Pathology, Peking University Health Science Center, Beijing, China.

Abstract

Ganoderma lucidum polysaccharides have protective effects against apoptosis in neurons exposed to ischemia/reperfusion injury, but the mechanisms are unclear. The goal of this study was to investigate the underlying mechanisms of the effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis. Hydrogen peroxide (H2O2) was used to induce apoptosis in cultured cerebellar granule cells. In these cells, ganoderma lucidum polysaccharides remarkably suppressed H2O2-induced apoptosis, decreased expression of caspase-3, Bax and Bim and increased that of Bcl-2. These findings suggested that ganoderma lucidum polysaccharides regulate expression of apoptosis-associated proteins, inhibit oxidative stress-induced neuronal apoptosis and, therefore, have significant neuroprotective effects.

KEYWORDS:

Bax; Bcl-2; Bim; H2O2; brain injury; caspase-3; cerebellar granule cells; cytochrome C; nerve regeneration; neural regeneration

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