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Clin Cosmet Investig Dermatol. 2017 Jul 18;10:267-273. doi: 10.2147/CCID.S141845. eCollection 2017.

Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period.

Author information

R&D Division, Kewpie Corporation, Sengawa-cho, Chofu-shi.
Department of Dermatology, Toho University Ohashi Medical Center, Ohashi, Meguro-ku, Tokyo, Japan.



Hyaluronan (HA) has critical moisturizing property and high water retention capacity especially for human skin. This study aimed to evaluate the effect of oral intake of HA.


The mean molecular weight (MW) of HA is 2 k and 300 k. Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks. The skin wrinkles were evaluated by image analysis of skin wrinkle replicas, and their skin condition was evaluated using a questionnaire survey.


During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group. After 8 weeks of ingestion, the HA 300 k group showed significantly diminished wrinkles compared with the placebo group. Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline.


The results suggest that oral HA (both HA 2 k and HA 300 k) inhibits skin wrinkles and improves skin condition.


dietary supplement; hyaluronic acid; molecular weight; skin; wrinkle volume

Conflict of interest statement

Disclosure Ms. Mariko Oe, Mr. Seigo Sakai, Mr. Hideto Yoshida, Ms. Haruna Kaneda, Ms. Nao Okado, Dr. Yasunobu Masuda are employees of Kewpie Coroporation. MD Osamu Urushibata is a professor of Toho University. The authors report no other conflicts of interest in this work.

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