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Int J Trichology. 2017 Jan-Mar;9(1):19-24. doi: 10.4103/ijt.ijt_79_16.

Prospective Analytical Controlled Study Evaluating Serum Biotin, Vitamin B12, and Folic Acid in Patients with Premature Canities.

Author information

1
Department of Dermatology and STD, University College of Medical Sciences and GTB Hospital, University of Delhi, New Delhi, India.
2
Department of Neurochemistry, Institute of Human Behaviour and Allied Sciences, New Delhi, India.

Abstract

BACKGROUND:

Premature canities is a common yet unfathomed disorder. The evidence for the role of micronutrient deficiency in premature canities is not well established.

AIM:

The present study was undertaken to evaluate the micronutrient levels in Indian patients with premature canities as compared to controls.

MATERIALS AND METHODS:

We conducted a case-control study in 52 self-reporting patients with premature canities (<20 years age). Micronutrient levels including serum Vitamin B12, biotin, and folic acid were assessed and compared among the patients and controls.

RESULTS:

We observed that mean serum Vitamin B12 (198.07 ± 88.98 pg/ml in cases vs. 343.07 ± 143.06 pg/ml in controls, P = 0.000), folic acid (6.22 ± 2.46 ng/ml in cases vs. 8.49 ± 4.18 ng/ml in controls, P = 0.01), and biotin (252.71 ± 18.79 pg/ml in cases vs. 266.47 ± 30.44 pg/ml in controls, P = 0.013) levels were significantly lower in cases as compared to the controls.

CONCLUSION:

In view of the dark hair and many prevailing myths, premature canities is a significant problem in Asians with profound psychosocial impact. This study unveils the association with Vitamin B12, folic acid, and biotin deficiencies. Larger studies are recommended to arrive on a logical conclusion.

KEYWORDS:

Biotin; India; Vitamin B12; graying of hair; micronutrient deficiency; premature canities

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