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Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9653-9658. doi: 10.1073/pnas.1708127114. Epub 2017 Jul 31.

Deep evolutionary conservation of autism-related genes.

Author information

1
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
2
Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
3
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; generobi@illinois.edu.
4
Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801.
5
Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

Abstract

E. O. Wilson proposed in Sociobiology that similarities between human and animal societies reflect common mechanistic and evolutionary roots. When introduced in 1975, this controversial hypothesis was beyond science's ability to test. We used genomic analyses to determine whether superficial behavioral similarities in humans and the highly social honey bee reflect common molecular mechanisms. Here, we report that gene expression signatures for individual bees unresponsive to various salient social stimuli are significantly enriched for autism spectrum disorder-related genes. These signatures occur in the mushroom bodies, a high-level integration center of the insect brain. Furthermore, our finding of enrichment was unique to autism spectrum disorders; brain gene expression signatures from other honey bee behaviors do not show this enrichment, nor do datasets from other human behavioral and health conditions. These results demonstrate deep conservation for genes associated with a human social pathology and individual differences in insect social behavior, thus providing an example of how comparative genomics can be used to test sociobiological theory.

KEYWORDS:

autism; evolution; honey bee; social behavior; transcriptomics

PMID:
28760967
PMCID:
PMC5594688
DOI:
10.1073/pnas.1708127114
[Indexed for MEDLINE]
Free PMC Article

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