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Nutrition. 2017 Sep;41:32-36. doi: 10.1016/j.nut.2017.03.007. Epub 2017 Apr 4.

Influence of selenium supplementation on patients with inflammation: A pilot double blind randomized study.

Author information

1
College of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil. Electronic address: renatagbonfreitas@yahoo.com.br.
2
College of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
3
College of Pharmaceutical Sciences, University of Sao Paulo (USP), São Paulo, Brazil.
4
College of Applied Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.

Abstract

OBJECTIVE:

The aim of the study was to analyze the effect of selenium supplementation on patients with inflammation receiving PN.

METHODS:

This double-blind randomized study included 20 hospitalized patients experiencing an inflammatory process while being fed by PN, who were monitored in three stages: first 72 h (0), day 7 (1), and day 14 (2) of PN. The supplemented patients group (G+S) received 60 μg/d (0.75 μmol) of selenium as selenious acid which was added to the PN bag. The nonsupplemented group (G-S) did not receive selenium. The concentration range of 84 to 100 μg/L (1.07-1.27 μmol/L) was used as a reference of plasma selenium.

RESULTS:

The study included 20 patients (8 G+S and 12 G-S) mainly diagnosed with cancer and/or sepsis. Most of them were hospitalized in the intensive care unit and were receiving PN for clinical reasons. Plasma selenium was greater in the G+S than in the G-S (P = 0.05) in two stages (0 and 1). Since the start of assessment, C-reactive protein (CRP) levels were elevated; however, there was no statistical difference in CRP values between groups (P > 0.05). There was no significant change of glutathione peroxidase over time or between groups (P > 0.05).

CONCLUSION:

The selenium concentration was greater in the G+S than in the G-S, acting independently from CRP behavior. However, supplementation was not enough to reach the reference values.

KEYWORDS:

C-reactive protein; Nutritional support; Parenteral nutrition; Selenium; Trace elements

PMID:
28760425
DOI:
10.1016/j.nut.2017.03.007
[Indexed for MEDLINE]

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