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Nutrition. 2017 Sep;41:14-23. doi: 10.1016/j.nut.2017.03.008. Epub 2017 Mar 29.

Hunger and satiety responses to high-fat meals after a high-polyunsaturated fat diet: A randomized trial.

Author information

1
Department of Nutritional Sciences, Texas Christian University, Fort Worth, Texas, USA.
2
Department of Food Science and Technology, University of Georgia, Athens, Georgia, USA; Department of Foods and Nutrition, University of Georgia, Athens, Georgia, USA.
3
Department of Foods and Nutrition, University of Georgia, Athens, Georgia, USA. Electronic address: jamie.cooper@uga.edu.

Abstract

OBJECTIVE:

Previous studies have shown that polyunsaturated fats (PUFAs) elicit a greater response in satiety after a single-meal challenge compared with other types of fats. The long-term effects of PUFAs on satiety, however, remain unknown. The aim of this study was to determine subjective and physiological hunger and satiety responses to high-fat (HF) meals before and after a 7-d PUFA-rich diet.

METHODS:

Twenty-six, healthy weight (body mass index 18-24.9 kg/m2), sedentary adults were randomly assigned to either a 7-d PUFA-rich diet (n = 8 men and n = 8 women) or a 7-d control diet (n = 5 men and n = 5 women). After a 3-d lead-in diet, participants reported for the baseline visit where anthropometrics, fasting visual analog scale (VAS) measurements, and a fasting blood sample were collected. Then, two HF meals (breakfast and lunch) were consumed. Postprandial blood draws and VAS measures were collected approximately every 30 min for 4 h after each meal, for a total of 8 h.

RESULTS:

From pre- to post-PUFA-rich diet, there was a decrease in fasting ghrelin (P < 0.05) and an increase in fasting peptide YY (PYY; P < 0.05); however, there were no changes in fasting insulin or leptin concentrations. The postprandial response for PYY was higher after the PUFA-rich diet visit compared to baseline (P < 0.01). However, there were no differences in the postprandial response for ghrelin, insulin, leptin, or VAS measures from pre- to post-diet in either the PUFA-rich diet or control (ns).

CONCLUSION:

A PUFA-rich diet consumed for 7 d favorably altered fasting and postprandial physiological markers of hunger and satiety; yet, did not alter subjective ratings of hunger or fullness.

KEYWORDS:

Ghrelin; Insulin; Leptin; PUFA; PYY; SFA; VAS

PMID:
28760423
DOI:
10.1016/j.nut.2017.03.008
[Indexed for MEDLINE]

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