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Exp Parasitol. 2017 Oct;181:47-56. doi: 10.1016/j.exppara.2017.07.007. Epub 2017 Jul 29.

Acaricidal, pediculicidal and larvicidal activity of synthesized ZnO nanoparticles using Momordica charantia leaf extract against blood feeding parasites.

Author information

1
Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous), Gandhi Nagar, 632 006, Vellore District, Tamil Nadu, India.
2
Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous), Gandhi Nagar, 632 006, Vellore District, Tamil Nadu, India; Centre for Ocean Research, Sathyabama University, Chennai, 600 119, Tamil Nadu, India.
3
Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous), Gandhi Nagar, 632 006, Vellore District, Tamil Nadu, India. Electronic address: reginamaryack@gmail.com.
4
Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, 632014, Tamil Nadu, India.

Abstract

The aim of the present study was to evaluate the acaricidal, pediculicidal and larvicidal effect of synthesized zinc oxide nanoparticles (ZnO NPs) using Momordica charantia leaf extract against the larvae of Rhipicephalus (Boophilus) microplus, adult of Pediculus humanus capitis, and the larvae of Anopheles stephensi, Culex quinquefasciatus. The ZnO NPs were characterized by using UV, XRD, FTIR and SEM-EDX. The SEM image confirms that the synthesized nanoparticles were spherical in shape with a size of 21.32 nm. The results of GC-MS analysis indicates the presence of the major compound of Nonacosane (C29H60) in the M. charantia leaf extract. Cattle tick, head lice and mosquito larvae were exposed to a varying concentrations of the synthesized ZnO NPs and M. charantia leaf extract for 24 h. Compared to the leaf aqueous extract, biosynthesized ZnO NPs showed higher toxicity against R. microplus, P. humanus capitis, An. stephensi, and Cx. Quinquefasciatus with the LC50 values of 6.87, 14.38, 5.42, and 4.87 mg/L, respectively. The findings revealed that synthesized ZnO NPs possess excellent anti-parasitic activity. These results suggest that the green synthesized ZnO NPs has the potential to be used as an ideal ecofriendly approach for the control of R. microplus, P. humanus capitis and the mosquito larvae of An. Stephensi and Cx. quinquefasciatus.

KEYWORDS:

Acaricidal; Larvicidal; Momordica charantia; Pediculicidal; ZnO NPs

PMID:
28760358
DOI:
10.1016/j.exppara.2017.07.007
[Indexed for MEDLINE]

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