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Int J Mol Sci. 2017 Jul 30;18(8). pii: E1657. doi: 10.3390/ijms18081657.

Polycomb Repressor Complex 2 in Genomic Instability and Cancer.

Author information

1
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece. veneti@imbb.forth.gr.
2
Embiodiagnostics Ltd., 71202 Heraklion, Greece. gkouskoukal@gmail.com.
3
Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological and Educational Institute of Athens, 12243 Athens, Greece. gkouskoukal@gmail.com.
4
Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece. eliopag@med.uoc.gr.
5
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 70013 Heraklion, Greece. eliopag@med.uoc.gr.

Abstract

Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies.

KEYWORDS:

DNA damage response; diet; enhancer of zeste homolog 2; inhibitors; polycomb; polycomb repressor complex 2

PMID:
28758948
PMCID:
PMC5578047
DOI:
10.3390/ijms18081657
[Indexed for MEDLINE]
Free PMC Article

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