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Obesity (Silver Spring). 2017 Sep;25(9):1594-1602. doi: 10.1002/oby.21926. Epub 2017 Jul 31.

Metabolomic Determinants of Metabolic Risk in Mexican Adolescents.

Author information

1
Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
2
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
3
Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
4
Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Morelos, México.
5
Michigan Regional Comprehensive Metabolomics Resource Core, University of Michigan Medical School, Ann Arbor, Michigan, USA.
6
Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
7
Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan, USA.

Abstract

OBJECTIVE:

The goal of this study was to identify metabolites associated with metabolic risk, separately by sex, in Mexican adolescents.

METHODS:

Untargeted metabolomic profiling was carried out on fasting serum of 238 youth aged 8 to 14 years, and metabolites associated with a metabolic syndrome risk z-score (MetRisk z-score) were identified separately for boys and girls, using the simulation and extrapolation algorithm. Associations of each metabolite with MetRisk z-score were examined using linear regression models that accounted for maternal education, child's age, and pubertal status.

RESULTS:

Of the 938 features identified in metabolomics analysis, 7 named compounds (of 27 identified metabolites) were associated with MetRisk z-score in girls, and 3 named compounds (of 14 identified) were associated with MetRisk z-score in boys. In girls, diacylglycerol (DG) 16:0/16:0, 1,3-dielaidin, myo-inositol, and urate corresponded with higher MetRisk z-score, whereas N-acetylglycine, thymine, and dodecenedioic acid were associated with lower MetRisk z-score. For example, each z-score increment in DG 16:0/16:0 corresponded with 0.60 (95% CI: 0.47-0.74) units higher MetRisk z-score. In boys, positive associations of DG 16:0/16:0, tyrosine, and 5'-methylthioadenosine with MetRisk z-score were found.

CONCLUSIONS:

Metabolites on lipid, amino acid, and carbohydrate metabolism pathways are associated with metabolic risk in girls. Compounds on lipid and DNA pathways correspond with metabolic risk in boys.

PMID:
28758362
PMCID:
PMC5573626
DOI:
10.1002/oby.21926
[Indexed for MEDLINE]
Free PMC Article

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