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Genes Chromosomes Cancer. 2017 Dec;56(12):841-845. doi: 10.1002/gcc.22485. Epub 2017 Sep 6.

Fusion of the genes BRD8 and PHF1 in endometrial stromal sarcoma.

Author information

1
Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Norway.
2
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
3
Faculty of Medicine, University of Oslo, Norway.

Abstract

We present a new endometrial stromal sarcoma (ESS)-associated genomic rearrangement involving chromosome arms 5p and 6p and leading to the formation of a BRD8-PHF1 fusion gene. The PHF1 (PHD finger protein 1) gene, from 6p21, is known to be rearranged in ESS in a promiscuous way inasmuch as it has been shown to recombine with JAZF1, EPC1, MEAF6, and now also with BRD8, in tumors of this type. In all rearrangements of PHF1, including the present one, a recurrent theme is that the entire coding part of PHF1 constitutes the 3' end of the fusion. BRD8 (bromodomain containing 8) encodes a protein which is involved in regulation of protein acetylation and/or histone acetyl transferase activity. All the genetic fusions identified so far in ESS appear to recombine genes involved in transcriptional regulation, that is, polycomb group complex-mediated and aberrant methylation/acetylation genes. This adds to the likelihood that the new BRD8-PHF1 shares the same pathogenetic mechanism as the other ESS-specific rearrangements.

PMID:
28758277
PMCID:
PMC5763393
DOI:
10.1002/gcc.22485
[Indexed for MEDLINE]
Free PMC Article

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