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Nat Rev Microbiol. 2017 Nov;15(11):689-696. doi: 10.1038/nrmicro.2017.75. Epub 2017 Jul 31.

Prediction of antibiotic resistance: time for a new preclinical paradigm?

Author information

1
AntibioTx A/S, Kemitorvet, Lyngby DK-2800, Denmark; and at The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK-2800, Denmark.
2
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby DK-2800, Denmark.
3
AntibioTx A/S, Kemitorvet, Lyngby DK-2800, Denmark.
4
Uppsala University, Department of Medical Biochemistry and Microbiology, Husargatan 3, SE-751 23 Uppsala, Sweden.

Abstract

Predicting the future is difficult, especially for evolutionary processes that are influenced by numerous unknown factors. Still, this is what is required of drug developers when they assess the risk of resistance arising against a new antibiotic candidate during preclinical development. In this Opinion article, we argue that the traditional procedures that are used for the prediction of antibiotic resistance today could be markedly improved by including a broader analysis of bacterial fitness, infection dynamics, horizontal gene transfer and other factors. This will lead to more informed preclinical decisions for continuing or discontinuing the development of drug candidates.

PMID:
28757648
DOI:
10.1038/nrmicro.2017.75
[Indexed for MEDLINE]

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