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Neurosci Biobehav Rev. 2018 Feb;85:21-33. doi: 10.1016/j.neubiorev.2017.07.009. Epub 2017 Jul 27.

Dual-transmitter systems regulating arousal, attention, learning and memory.

Author information

1
The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia. Electronic address: sherie.ma@florey.edu.au.
2
'Lendület' Laboratory of Systems Neuroscience, Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary.
3
Department of Physiology, New York Medical College, Valhalla, NY, USA.
4
Department of Life Sciences, Imperial College London, London, UK.
5
The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia; Department of Anatomy and Neuroscience, The University of Melbourne, Victoria, Australia. Electronic address: andrew.gundlach@florey.edu.au.

Abstract

An array of neuromodulators, including monoamines and neuropeptides, regulate most behavioural and physiological traits. In the past decade, dramatic progress has been made in mapping neuromodulatory circuits, in analysing circuit dynamics, and interrogating circuit function using pharmacogenetic, optogenetic and imaging methods This review will focus on several distinct neural networks (acetylcholine/GABA/glutamate; histamine/GABA; orexin/glutamate; and relaxin-3/GABA) that originate from neural hubs that regulate wakefulness and related attentional and cognitive processes, and highlight approaches that have identified dual transmitter roles in these behavioural functions. Modulation of these different neural networks might be effective treatments of diseases related to arousal/sleep dysfunction and of cognitive dysfunction in psychiatric and neurodegenerative disorders.

KEYWORDS:

Acetylcholine; Arousal and attention; GABA; Glutamate; Histamine; Hypocretin; Learning and memory; Orexin; Relaxin-3

PMID:
28757457
PMCID:
PMC5747977
DOI:
10.1016/j.neubiorev.2017.07.009
[Indexed for MEDLINE]
Free PMC Article

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