Format

Send to

Choose Destination
Biochem Biophys Res Commun. 2017 Sep 23;491(3):636-641. doi: 10.1016/j.bbrc.2017.07.151. Epub 2017 Jul 28.

Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice.

Author information

1
Research Center for Neurobiology, Xuzhou Medical University, No. 209, Tongshan Road, Yunlong District, Xuzhou 221004, Jiangsu, People's Republic of China.
2
Anesthesiology Department, Xuzhou Medical University, No. 209, Tongshan Road, Yunlong District, Xuzhou 221004, Jiangsu, People's Republic of China.
3
Department of Neurology, Affiliated Hospital of Xuzhou Medical University, No. 99, Huaihai West Road, Quanshan District, Xuzhou 221002, Jiangsu, People's Republic of China.
4
Research Center for Neurobiology, Xuzhou Medical University, No. 209, Tongshan Road, Yunlong District, Xuzhou 221004, Jiangsu, People's Republic of China. Electronic address: wenxi_yao@163.com.

Abstract

Aging is accompanied by deficits in cognitive function and neuronal degeneration or loss. Quercetin is a flavonoid that exhibits powerful antioxidant activity. This study evaluated the protective effects and mechanisms of quercetin in d-galactose-induced neurotoxicity in mice. Quercetin was administered daily at doses of 20 or 50 mg/kg in d-galactose-injected (50 mg/kg/subcutaneous (s.c.)) mice for eight weeks. Morris water maze tests demonstrated that quercetin significantly improved learning and memory compared to d-galactose-treated control mice. Quercetin also prevented changes in the neuronal cell morphology and apoptosis in the hippocampus as well as increased the expression of Nrf2, HO-1 and SOD in d-galactose-treated mice. Treatment with the Nrf2 inhibitor Brusatol reversed the effects of quercetin on HO-1 and SOD expression as well as neuronal cell protection. In conclusion, quercetin protected mice from d-galactose-induced cognitive functional impairment and neuronal cell apoptosis via activation of the Nrf2-ARE signaling pathway.

KEYWORDS:

Apoptosis; Morris water maze; Mouse brain aging; Nrf2-ARE; Quercetin; d-galactose

PMID:
28757412
DOI:
10.1016/j.bbrc.2017.07.151
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center