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Mol Genet Metab. 2017 Nov;122(3):28-38. doi: 10.1016/j.ymgme.2017.07.008. Epub 2017 Jul 25.

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.

Author information

1
Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
2
SRI International, Biosciences Division, Menlo Park, CA, USA.
3
Division of Hematology/Oncology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: kmsakamo@stanford.edu.

Abstract

The role of non-coding Ribonucleic Acids (ncRNAs) in biology is currently an area of intense focus. Hematopoiesis requires rapidly changing regulatory molecules to guide appropriate differentiation and ncRNA are well suited for this. It is not surprising that virtually all aspects of hematopoiesis have roles for ncRNAs assigned to them and doubtlessly much more await characterization. Stem cell maintenance, lymphoid, myeloid and erythroid differentiation are all regulated by various ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and various transposable elements within the genome. As our understanding of the many and complex ncRNA roles continues to grow, new discoveries are challenging the existing classification schemes. In this review we briefly overview the broad categories of ncRNAs and discuss a few examples regulating normal and aberrant hematopoiesis.

PMID:
28757239
PMCID:
PMC5722683
DOI:
10.1016/j.ymgme.2017.07.008
[Indexed for MEDLINE]
Free PMC Article

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