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Am J Hum Genet. 2017 Aug 3;101(2):274-282. doi: 10.1016/j.ajhg.2017.06.013. Epub 2017 Jul 27.

Continuity and Admixture in the Last Five Millennia of Levantine History from Ancient Canaanite and Present-Day Lebanese Genome Sequences.

Author information

1
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Electronic address: mh25@sanger.ac.uk.
2
The Sidon excavation, Saida, Lebanon.
3
Department of Archaeology and Anthropology, University of Cambridge, Cambridge CB2 1QH, UK.
4
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
5
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
6
Department of Anatomy, University of Otago, Dunedin 9054, New Zealand.
7
Department of Archaeology, Anthropology, and Forensic Science, Bournemouth University, Talbot Campus, Poole BH12 5BB, UK.
8
The Lebanese American University, Chouran, Beirut 1102 2801, Lebanon; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
9
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. Electronic address: cts@sanger.ac.uk.

Abstract

The Canaanites inhabited the Levant region during the Bronze Age and established a culture that became influential in the Near East and beyond. However, the Canaanites, unlike most other ancient Near Easterners of this period, left few surviving textual records and thus their origin and relationship to ancient and present-day populations remain unclear. In this study, we sequenced five whole genomes from ∼3,700-year-old individuals from the city of Sidon, a major Canaanite city-state on the Eastern Mediterranean coast. We also sequenced the genomes of 99 individuals from present-day Lebanon to catalog modern Levantine genetic diversity. We find that a Bronze Age Canaanite-related ancestry was widespread in the region, shared among urban populations inhabiting the coast (Sidon) and inland populations (Jordan) who likely lived in farming societies or were pastoral nomads. This Canaanite-related ancestry derived from mixture between local Neolithic populations and eastern migrants genetically related to Chalcolithic Iranians. We estimate, using linkage-disequilibrium decay patterns, that admixture occurred 6,600-3,550 years ago, coinciding with recorded massive population movements in Mesopotamia during the mid-Holocene. We show that present-day Lebanese derive most of their ancestry from a Canaanite-related population, which therefore implies substantial genetic continuity in the Levant since at least the Bronze Age. In addition, we find Eurasian ancestry in the Lebanese not present in Bronze Age or earlier Levantines. We estimate that this Eurasian ancestry arrived in the Levant around 3,750-2,170 years ago during a period of successive conquests by distant populations.

KEYWORDS:

Bronze Age; Lebanon; Near East; Phoenicians; Sidon; aDNA; population genetic history; whole-genome sequences

Comment in

PMID:
28757201
PMCID:
PMC5544389
DOI:
10.1016/j.ajhg.2017.06.013
[Indexed for MEDLINE]
Free PMC Article

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