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Vaccine. 2017 Aug 24;35(36):4659-4669. doi: 10.1016/j.vaccine.2017.07.045. Epub 2017 Jul 28.

Immune correlates of protection for dengue: State of the art and research agenda.

Author information

1
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA; Department of Biology, University of Florida, Gainesville, FL 32611, USA.
2
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA. Electronic address: eharris@berkeley.edu.
3
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435, USA.
4
Merck Research Laboratories, Merck & Co., Inc., Kenilworth, NJ, USA.
5
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
6
Departments of Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Vanderbilt University, Nashville, TN, USA.
7
Department of Biology and Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
8
Takeda Pharmaceutical Company Limited, Cambridge, MA 02139, USA.
9
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
10
Departments of Medicine, Molecular Microbiology, and Pathology and Immunology, The Andrew M. and Jane M. Bursky Center for Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.
11
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
12
MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom.
13
Vaccine and Infectious Disease Institute, Hutchinson Research Center, Seattle, WA 98109, USA; Department of Biostatistics, University of Washington, Seattle, WA 98109, USA.
14
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
15
Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.
16
Research & Development, Sanofi Pasteur, 69007 Lyon, France.
17
Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
18
Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
19
Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
20
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
21
Global Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile 69280, France.
22
Vaxconsult, Doylestown, PA, USA; University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
23
Clinical Trials and Pharmacovigilance Division, Instituto Butantan, São Paulo, Brazil; Pediatrics Department, School of Medicine of University of São Paulo, São Paulo, Brazil.
24
Department of Epidemiology and Biostatistics, Indiana University Bloomington School of Public Health, Bloomington, IN, USA.
25
Structural Virology Unit, Department of Virology, Institut Pasteur, Paris 75724, France.
26
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Medicine, University of California, San Francisco, CA, USA.
27
Institute for Immunology and Informatics, Department of Cell and Molecular Biology, University of Rhode Island, Providence, RI 02903, USA.
28
Vaccine Discovery and Development, GSK Vaccines, US R&D Center, Rockville, MD 20850, USA.
29
Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College London, London, United Kingdom.
30
La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
31
Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Department of Microbiology and Immunology, University of Melbourne, Doherty Institute for Infection and Immunity, Parkville, Victoria 3010, Australia.
32
Division of Vaccines and Related Products Applications, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
33
Department of Medicine, Upstate Medical University of New York, Syracuse, NY 13210, USA.
34
Department of Microbiology and Immunology, University of Melbourne, Doherty Institute for Infection and Immunity, Parkville, Victoria 3010, Australia.
35
Systems Genomics and Bioinformatics Unit, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Trans-NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA.
36
Initiative for Vaccine Research, World Health Organization, Geneva, Switzerland.
37
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
38
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore; London School of Hygiene and Tropical Medicine, London, United Kingdom.
39
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; International Vaccine Institute, Seoul, South Korea.

Abstract

Dengue viruses (DENV1-4) are mosquito-borne flaviviruses estimated to cause up to ∼400 million infections and ∼100 million dengue cases each year. Factors that contribute to protection from and risk of dengue and severe dengue disease have been studied extensively but are still not fully understood. Results from Phase 3 vaccine efficacy trials have recently become available for one vaccine candidate, now licensed for use in several countries, and more Phase 2 and 3 studies of additional vaccine candidates are ongoing, making these issues all the more urgent and timely. At the "Summit on Dengue Immune Correlates of Protection", held in Annecy, France, on March 8-9, 2016, dengue experts from diverse fields came together to discuss the current understanding of the immune response to and protection from DENV infection and disease, identify key unanswered questions, discuss data on immune correlates and plans for comparison of results across assays/consortia, and propose a research agenda for investigation of dengue immune correlates, all in the context of both natural infection studies and vaccine trials.

KEYWORDS:

Dengue virus; Immune correlates of protection; Immune correlates of risk; Natural infection; Vaccine

PMID:
28757058
PMCID:
PMC5924688
DOI:
10.1016/j.vaccine.2017.07.045
[Indexed for MEDLINE]
Free PMC Article

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