Grape Seed Procyanidin Extract Reduces Arsenic-Induced Renal Inflammatory Injury in Male Mice

Biomed Environ Sci. 2017 Jul;30(7):535-539. doi: 10.3967/bes2017.071.

Abstract

The aim of the present study is to evaluate the ability and mechanism by which grape seed procyanidin extract (GSPE) relieves arsenic trioxide (As2O3)-induced renal inflammatory injury. Therefore, male Kunming mice were treated with As2O3 and/or GSPE by gavage for 5 weeks. Mice were then sacrificed and inflammatory cytokines of kidneys were examined by ELISA, whereas the expression levels of molecules involved in the nuclear factor (NF)-κB signaling pathway were evaluated by both qRT-PCR and Western blot. Our results indicate that GSPE prevents As2O3-mediated renal inflammatory injury by inhibiting activation of the NF-κB signaling pathway and inflammatory cytokine production, while promoting expression of anti-inflammatory cytokines.

MeSH terms

  • Animals
  • Arsenic / toxicity*
  • Grape Seed Extract / therapeutic use*
  • Inflammation / chemically induced*
  • Inflammation / drug therapy
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / drug therapy
  • Male
  • Mice
  • Proanthocyanidins / therapeutic use*

Substances

  • Grape Seed Extract
  • Grape Seed Proanthocyanidins
  • Proanthocyanidins
  • Arsenic