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Cancer Res. 2017 Nov 15;77(22):6065-6068. doi: 10.1158/0008-5472.CAN-17-1207. Epub 2017 Jul 28.

Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments.

Author information

1
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado. james.degregori@ucdenver.edu.

Abstract

In a recent article in Science, Tomasetti and colleagues present an expanded model for cancer risk, which they claim demonstrates the relative contribution of mutations caused by replication errors, environment, and heredity. The foundation of this model is the theory that the overwhelming driver of cancer risk is mutations. This perspective will present experimental evidence and evolutionary theory to challenge the basis of this underlying theory. An argument will be presented that the mutation-centric model of cancer suggests unrealistic solutions to cancer and distracts the research community from more promising approaches that consider tissue context. Cancer Res; 77(22); 6065-8. ©2017 AACR.

PMID:
28754675
PMCID:
PMC5690828
DOI:
10.1158/0008-5472.CAN-17-1207
[Indexed for MEDLINE]
Free PMC Article

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