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Trends Cogn Sci. 2017 Oct;21(10):760-778. doi: 10.1016/j.tics.2017.06.006. Epub 2017 Jul 25.

Mapping the Consequences of Impaired Synaptic Plasticity in Schizophrenia through Development: An Integrative Model for Diverse Clinical Features.

Author information

1
Department of Psychology, University of California at Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, USA. Electronic address: JForsyth@mednet.ucla.edu.
2
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

Schizophrenia is associated with alterations in sensory, motor, and cognitive functions that emerge before psychosis onset; identifying pathogenic processes that can account for this multi-faceted phenotype remains a challenge. Accumulating evidence suggests that synaptic plasticity is impaired in schizophrenia. Given the role of synaptic plasticity in learning, memory, and neural circuit maturation, impaired plasticity may underlie many features of the schizophrenia syndrome. Here, we summarize the neurobiology of synaptic plasticity, review evidence that plasticity is impaired in schizophrenia, and explore a framework in which impaired synaptic plasticity interacts with brain maturation to yield the emergence of sensory, motor, cognitive, and psychotic features at different times during development in schizophrenia. Key gaps in the literature and future directions for testing this framework are discussed.

PMID:
28754595
PMCID:
PMC5610626
DOI:
10.1016/j.tics.2017.06.006
[Indexed for MEDLINE]
Free PMC Article

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